Snapshot 1: biphasic decay where the first phase is slower than the second
Snapshot 2: biphasic growth where the first phase is faster than the second
Snapshot 3: biphasic growth where the first phase is slower than the second
Several biochemical reactions and biological processes can be considered biphasic; that is, they have both fast and slow kinetics and a transition between them. If the two phases follow first-order kinetics with exponential rate constants
, and the transition between them occurs at time
, then the process's product
can be described by
. In growth or accumulation processes the terms on the right side of the equation are all positive and in decay or degradation they are negative.
This Demonstration helps the user to visualize the progress of such processes. It plots decay or growth curves by setting the exponential rate constants of the two phases,
, and the transition time,
. The user can choose between decay and growth processes with a selector switch and enter the values of the rate constants and the transition time using sliders. The maximum value displayed on the
axes is also entered with sliders.
Notice that if
is set to 0, then the plot will be of a conventional first-order kinetics having an exponential rate constant
is set to a value greater than or equal to the
axis maximum, then the plot will be of a conventional first-order kinetics having an exponential rate constant
M. A. J. S. von Boekel, Kinetic Modeling of Reactions in Foods
, Boca Raton: CRC Press, 2008.
M. G. Corradini, M. D. Normand, and M. Peleg, "Modeling Non-Isothermal Heat Inactivation of Microorganisms Having Biphasic Isothermal Survival Curves," International Journal of Food Microbiology
(3), 2007 pp. 391–399.