Doehlert Design for Wet Pelletization

Consider the experimental design problem in which there are three factors: (1) impeller speed (in rpm) with associated variable , such that the lower and upper levels are 250 and 400, respectively, (2) amount of binding solution (in %) with associated variable , such that the lower and upper levels are 60 and 70, respectively, (3) pelletization time (in min) with associated variable , such that the lower and upper levels are 5 and 20, respectively.
Pelletization experiments using Doehlert design scheme determine one parameter: the mean pellet size (in mm).
This Demonstration computes the quadratic model by multilinear regression; the response versus , , and is given by:
You can set the value of one of the variables (say ) and the Demonstration will display the contour plot of the response versus the other two variables (and ).


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G. A. Lewis, D. Mathieu, and R. Phan–Than–Luu, Pharmaceutical Experimental Design, Drugs and the Pharmaceutical Sciences, Vol 92, New York: Marcel Dekker, 1999.
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