Hodgkin-Huxley Action Potential Model

The voltage across membranes of excitable cells (e.g. nervous system, muscles, heart, endocrine system) transiently changes, creating a pulse-like wave called an "action potential". The action potential serves as a major signal for the initiation of many cellular and intercellular processes. The canonical mathematical-physical model of the phenomenon was presented by Alan Hodgkin and Andrew Huxley in 1952 in a series of seminal papers [2], where membrane potenial dynamics is described in terms of voltage-dependent ionic conductance, dominated by four coupled ordinary differential equations. In the realization presented here, the action potential is trigerred by a short current stimulus. Shown are time evolutions of membrane voltage (blue trace) and conductance gates (, , and ).