Antithrombin III-Thrombin Bonding with Heparin Catalysis

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Nesheim [1] showed how heparin, a common ingredient in blood-thinning medicines, catalyzes and changes the rate law of the antithrombin III-thrombin binding reaction. This is summarized by three equations that represent the observed rates for catalysis. The reaction can be modeled by a piecewise function showing three possible reaction orders in the catalysis by heparin. You can vary the sliders for the combined mass of antithrombin III and thrombin and the rate order for different amounts of added heparin.

Contributed by: Louis Hess, K. G. Foley and Cullen Peterson (January 2024)
Open content licensed under CC BY-NC-SA




[1] M. E. Nesheim, "A Simple Rate Law That Describes the Kinetics of the Heparin-Catalyzed Reaction between Antithrombin III and Thrombin," The Journal of Biological Chemistry, 258(23), 1983 pp. 14708–14717. doi:10.1016/S0021-9258(17)43920-2.

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