1. Priority shall be assigned on the basis of the atomic number. The higher the atomic number, the higher the priority of the substituent; with the same atomic number (isotopes), priority is given to the isotope with the highest atomic mass.

2. If the two atoms compared are identical, it is then necessary to take account of the atoms to which they are bonded. We proceed to the comparison of the successive atoms in the chains up to the point in which a difference in priority occurs. It is useful, to facilitate comparison, to associate each atom of the chain with its atomic number, followed in parentheses by the atomic numbers of the three atoms that are bound to it, in decreasing order.

3. Multiple bonds are transformed into an equivalent number of single bonds, to which is joined a replica of the previously connected atom (usually enclosed in square brackets).

Different organic compounds can be selected with the drop-down menu:

Along with "linear chains", "branched chains" or "chain with double or triple bonds (formally converted)," it is possible to use "carbon atoms of substituent" to change the atom of the substituent chain and thus evaluate the priority of the elements connected to it. The numbering begins with the atom directly involved in the double bond or chiral carbon; the bond relative to this first atom is shown in blue.

Selecting "formal transformation of double and triple bonds" instead allows you to observe the transformation of double and triple bonds to single bonds. In line with the CIP convention 3, the evolution of the structural formulas can be followed with the slider "evolution of the structural formula."

The atom responsible for the first change in the difference in priority and, therefore, responsible for assigning the priority, is represented in green, as well as the atomic number now associated. Shown in orange are the atom and its relative atomic number, which would have had priority if not previously assigned.