Diffusion Rates Across the Blood-Brain Barrier
The blood-brain barrier is a semipermeable membrane that separates the brain from the capillaries that pass through it. A relevant question in medical technology is the rate at which drugs are able to pass through this barrier, which subsequently informs studies in pharmacology and physiology. The Demonstration illustrates a series of structural variables applied to the cells in a simulated human brain. The comparative rates of diffusion in a variety of biologically active compounds were found by applying an integrated form of Fick's Law, given by[more]
where is the concentration of the compound in the brain, is the concentration of the compound in the capillaries, is the diffusion coefficient, is the blood-brain barrier surface area, is the thickness and is the volume of the brain.[less]
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