Dynamics of an Enzymatic Aerated Reactor

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This Demonstration shows the influence of gassing rate and stirrer speed on an enzymatic aerated reactor. The transfer coefficient is a function of and .

Contributed by: R. Ricardo Sánchez (August 2022)
Open content licensed under CC BY-NC-SA



The solubility of oxygen in aqueous solutions at ambient temperature and pressure is only between 8 and 10 ppm. This amount of oxygen is quickly consumed in aerobic cultures and must be constantly replaced by sparging (bubbling air through the liquid) [1].


: substrate concentration (g/L)

: product concentration (g/L)

: dissolved oxygen concentration (mg/L)

: saturation dissolved oxygen concentration (mg/L)

: critical dissolved oxygen concentration (mg/L)

: substrate uptake rate (g/L h)

The transfer coefficient varies with and according to:

with .

The model that includes reaction kinetics and mass balances is described in [2].


[1] P. M. Doran, Bioprocess Engineering Principles, Boston: Elsevier, 1995.

[2] I. J. Dunn, E. Heinzle, J. Ingham and J. E. Prvenosil, Biological Reaction Engineering, 2nd ed., Weinheim, Germany: VCH Verlagsgesellschaft mbH, 2003.

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