Formation of Acetals under Acid Conditions
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This Demonstration considers the chemical kinetics of the formation of acetals from hemiacetals. This reaction, unlike the formation of hemiacetals [1], can only take place with acid catalysis. In fact, this reaction is a substitution reaction, replacing the –OH group with the –OR group, and an acid solution is necessary to transform –OH into , thus obtaining a good leaving group. If an ion is formed and an excess of charge is present, a colored shadow identifies the charge and its center: purple indicates an excess of positive charge, while green indicates an excess of negative charge.
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Contributed by: D. Meliga, V. Giambrone, L. Lavagnino and S. Z. Lavagnino
Additional contribution by: F. Calcagno (I.T.I.S. Artom) (January 2024)
Open content licensed under CC BY-NC-SA
Snapshots
Details
Snapshot 1: first step of the acid catalysis, a proton transfer to start the reaction
Snapshot 2: second step of the acid catalysis, a water molecule loss to form the carbocation
Snapshot 3: third step of the acid catalysis, a nucleophile attack between the carbocation and the methanol
Snapshot 4: final step of the acid catalysis, a proton loss to produce the acetal
References: [1] Addizioni nucleofile ai chetoni https://www.youtube.com/watch?v=dKQLBPJ8Jew&list=PLswwssc6Q2ybl1IVEY56LVc16XsDKzFr-&index=48 [2] Hydrates, Hemiacetals, and Acetals https://www.masterorganicchemistry.com/2010/05/28/acetals-hemiacetals-hydrates/
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