Kinetics of DNA Methylation in Eukaryotes

The methylation and demethylation of the 5-position in cytosine, which stops the expression of the gene in vertebrates, is passed along on one strand of DNA. The daughter cells may spontaneously methylate (at rate ) or demethylate (at rate ). At the step of successive divisions, the probabilities of the cell having one, two, or none of its labile sites methylated are denoted by , , and , which give the proportion of homomethylated, hemi-methylated, and unmethylated sites, respectively, in generation .


  • [Snapshot]
  • [Snapshot]
  • [Snapshot]


The kinetic equations,
are recast as:
and the time evolution of is calculated by recursion.
[1] S. P. Otto and V. Walbot, "DNA Methylation in Eukaryotes: Kinetics of Demethylation and de Novo Methylation During the Life Cycle," Genetics, 124(2), 1990 pp. 429–437. www.genetics.org/content/124/2/429.full.pdf.
    • Share:

Embed Interactive Demonstration New!

Just copy and paste this snippet of JavaScript code into your website or blog to put the live Demonstration on your site. More details »

Files require Wolfram CDF Player or Mathematica.

Mathematica »
The #1 tool for creating Demonstrations
and anything technical.
Wolfram|Alpha »
Explore anything with the first
computational knowledge engine.
MathWorld »
The web's most extensive
mathematics resource.
Course Assistant Apps »
An app for every course—
right in the palm of your hand.
Wolfram Blog »
Read our views on math,
science, and technology.
Computable Document Format »
The format that makes Demonstrations
(and any information) easy to share and
interact with.
STEM Initiative »
Programs & resources for
educators, schools & students.
Computerbasedmath.org »
Join the initiative for modernizing
math education.
Step-by-Step Solutions »
Walk through homework problems one step at a time, with hints to help along the way.
Wolfram Problem Generator »
Unlimited random practice problems and answers with built-in step-by-step solutions. Practice online or make a printable study sheet.
Wolfram Language »
Knowledge-based programming for everyone.
Powered by Wolfram Mathematica © 2018 Wolfram Demonstrations Project & Contributors  |  Terms of Use  |  Privacy Policy  |  RSS Give us your feedback
Note: To run this Demonstration you need Mathematica 7+ or the free Mathematica Player 7EX
Download or upgrade to Mathematica Player 7EX
I already have Mathematica Player or Mathematica 7+