Genetic Toggle Switch

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This Demonstration implements a mathematical model of the "genetic toggle switch" gene network. The genetic toggle switch consists of two genes, each of which encodes for a protein that represses the other's gene expression. Because of the even number of components in the circuit, there is a net positive feedback, which can give rise to bistable behavior for certain parameter values. The behavior of each repressor concentration is visualized as a function of time.

Contributed by: Simon Mochrie (May 2011)
Open content licensed under CC BY-NC-SA



The genetic toggle switch was described and implemented in E. coli in [1].


[1] T. S. Gardner, C. R. Cantor, and J. J. Collins, "Construction of a Genetic Toggle Switch in Escherichia coli," Nature, 403, 2000 pp. 339–342.

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