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DNA Screening Incidentalome

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Genomic medicine offers affordable test arrays that screen for hundreds of thousands of genetic risk factors. However, further tests needed to distinguish between true positive and false positive results are more costly and may entail various inconveniences or even the iatrogenic risks of using advanced diagnostic techniques.

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Modify the probabilities of individual tests being true positive or false positive. The blue line gives the expected percentage of false positives in at least one test in a screening array. The red line gives the expected percentage of at least one true positive result. Increase the number of tests per screening array to increase both percentages.

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Contributed by: Michael Schreiber (March 2011)
Open content licensed under CC BY-NC-SA

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Incidental findings may help patients, and a radiologist will pay attention to all incidentalomas detected as most of them indicate unexpected real mass; however, most DNA results just indicate potential risks instead.

The Incidentalome: A Threat to Genomic Medicine

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