Pharmacokinetics of Drug Clearance

Initializing live version
Download to Desktop

Requires a Wolfram Notebook System

Interact on desktop, mobile and cloud with the free Wolfram Player or other Wolfram Language products.

This Demonstration shows the variation of drug concentration in human plasma of an IV bolus-administered drug over a one-hour time period. Drug-plasma concentration is dependent on the dosage (dose), volume of distribution (Vd) and clearance of the drug (CL). The volume of distribution determines the drug's plasma concentration, while clearance describes the speed in which the drug is cleared from the plasma by the body. This Demonstration might be used as a reference for medical personnel to estimate how quickly an administered drug is processed by the human body. A body mass of 70 kg is assumed.

Contributed by: Morgan DeMeulemeester, Selina Lu and Lily Haghpassand (January 2023)
Open content licensed under CC BY-NC-SA



Snapshot 1: pharmacokinetics of cannabinoids; clearance (L/hr) = 14, volume of distribution (L/kg) = 10 and dosage (mg) = 5

Snapshot 2: pharmacokinetics of albuterol; clearance (L/hr) = 29, volume of distribution (L/kg) = 2.2 and dosage (mg) = 2.5

Snapshot 3: pharmacokinetics of sertraline; clearance (L/hr) = 76, volume of distribution (L/kg) = 20 and dosage(mg) = 25

Snapshot 4: pharmacokinetics of trazodone; clearance (L/hr) = 6, volume of distribution (L/kg) = 1 and dosage (mg) = 30

Feedback (field required)
Email (field required) Name
Occupation Organization
Note: Your message & contact information may be shared with the author of any specific Demonstration for which you give feedback.